Accepted papers
Kirmes I, Hung GCC, Hahn A, Dai CY, Campbell D, Ahier A, Lee RSY, Palmer A, Zuryn S (2025) The microRNA miR-71 suppresses maladaptive UPRmt signaling through both cell-autonomous and cell-non-autonomous mechanisms. Nature Communications. In Press.
Saber SH*, Yak N*, Yong XLH, Bong R, Leeson H, Dai CY, Binder T, Lu S, Purushothaman R, Lenaerts A, Almeida-Souza L, Koludarova L, Er S, Hlushchuk I, Gaudin A, Singh S, Nyman TA, Harmer JR, Zuryn S, Wolvetang E, Talbo GH, Airavaara M, Battersby BJ, van Waardenberg AJ, Anggono V, Balistreri G, Joensuu M (2025) DDHD2 provides a flux of saturated fatty acids for neuronal energy and functions. Nature Metabolism. 7(10), 2117-2141. (*Co-first) Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages.Abrol R, Afroz SF, Curson JEB, Raven KD, Das Gupta K, Gunther KS, Jones A, Reid RC, Xiong Z, Gunter JH, Engel JA, Engwerda CR, Blumenthal A, Fairlie DP, Parton RG, Zuryn S, Kapetanovic R, Ramnath D, Sweet MJ. J Cell Sci. 2025 Oct 1;138(19):jcs264376. The mechanisms and roles of mitochondrial dynamics in C. elegans.Campbell D, Zuryn S. Semin Cell Dev Biol. 2024 Mar 15;156:266-275. doi: 10.1016/j.semcdb.2023.10.006. Epub 2023 Oct 31. Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function. Matsunaga Y, Qadota H, Ghazal N, Lesanpezeshki L, Dorendorf T, Moody JC, Ahier A, Matheny CJ, Vanapalli SA, Zuryn S, Mayans O, Kwong JQ, Benian GM. Commun Biol. 2024 Oct 17;7(1):1342. . C. elegans as a model for health and disease. Zuryn S. Semin Cell Dev Biol. 2024 Feb 15;154(Pt A):1-3. Hahn A., Hung GCC., Ahier A., Dai CY., Kirmes I., Forde BM., Campbell D., Lee RSY., Sucic J., Onraet T., Zuryn S. (2024) Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans. Cell Metabolism. S1550-4131(24)00291-2. Dai CY, Zhang H, Zuryn S. (2024) SoMarker: a genetic marker searching tool for Caenorhabditis elegans. G3 Genes|Genomes|Genetics. 14(10):jkae197. C. elegans as a model to study mitochondrial biology and disease.Onraet T, Zuryn S. Semin Cell Dev Biol. 2024 Feb 15;154(Pt A):48-58. Dai CY., Ng CC., Hung GCC., Kirmes I., Hughes LA., Du Y., Brosnan CA., Ahier A., Hahn A., Haynes CM., Rackham O., Filipovska A., Zuryn S. (2023) ATFS-1 prioritises mitochondrial genome repair to enhance cellular robustness in C. elegans. Nature Cell Biology. (In Press). C. elegans as a model to study mitochondrial biology and disease.Onraet T, Zuryn S.Semin Cell Dev Biol. 2024 Feb 15;154(Pt A):48-58. doi: 10.1016/j.semcdb.2023.04.006. Epub 2023 Nguyen-Dien GT, Kozul KL, Cui Y, Townsend B, Kulkarni PG, Ooi SS, Marzio A, Carrodus N, Zuryn S, Pagano M, Parton RG, Lazarou M, Millard SS, Taylor RW, Collins BM, Jones MJ, Pagan JK. (2023) FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. EMBO Journal. 42(13):e112767. Onraet T., Zuryn S (2023) C. elegans as a model to study mitohcondrial biology and disease. Semin Cell Dev Biol. S1084-9521(23)00101-5. Kirmes I. & Zuryn S (2022) LONP-1 aids propagation of deleterious mtDNA. Nature Cell Biology. 24(2):127–128. Richman TR., Ermer JA., Siira S., Kuznetsova I., Brosnan CA., Rossetti G., Baker J., Perks K., Szappanos HC., Viola HM., Whiley NG., Hool LC., Zuryn S., Rackham O., Filipovska A. (2021) Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan. Aging Cell. :e13408. doi: 10.1111/acel.13408.
Ahier A., Dai CY., Kirmes I., Cummins N., Götz J., Hung GCC., Zuryn S. (2021) PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome. Cell Reports. 35(9): 109203. doi: 10.1016/j.celrep.2021.109203.Featured as the issue cover.Featured in “preLights” by The Company of Biologists.
Brosnan CA., Palmer AJ., Zuryn S. (2021) Cell-type-specific profiling of loaded miRNAs from Caenorhabditis elegans reveals spatial and temporal flexibility in Argonaute loading. Nature Communications. 12:2914.Faculty of 1000 recommended. Cummins N., Tweedie A., Zuryn S., Bertran-Gonzalez, J., Götz J. (2019) Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria. EMBO Journal. 38(3). pii: e99360.
Hahn A., Zuryn S. (2019) Cellular mitochondrial genomic landscape in disease. Trends in Cell Biology. 29(3):227-240. Hahn A., Zuryn S. (2019) Mitochondrial genome (mtDNA) mutations that generate reactive oxygen species. Antioxidants. 8(9). e392. doi: 0.3390/antiox8090392
Ahier A., Dai CY., Tweedie A., Bezawork-Geleta A., Kirmes I., Zuryn S. (2018) Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism. Nature Cell Biology. 20(3):352-360. Featured as the issue cover.Commentary in The Scientist.
Bezawork-Geleta A., Wen H., Dong L., Bing Y., Vider J., Boukalova S., Krobova L., Vanova K., Zobalova R., Sobol M., Hozak P., Novais SM., Caisova V., Abaffy P., Naraine R., Pang Y., Zaw T., Zhang P., Sindelka R., Kubista M., Zuryn S., Molloy MP., Berridge MV., Pacak K., Rohlena J., Park S., Neuzil J. (2018) Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints. Nature Communications. 9:2221.
Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. (2014). Sequential histone-modifying activities determines the robustness of transdifferentiation. Science. 345(6198):826-829. Commentary in Developmental Cell.Faculty of 1000 recommended.
Wilkinson R., Wang X., Kassianos AJ., Zuryn S., Roper KE., Osborne A., Sampangi S., Francis L., Raghunath V., Healy H. (2014). Laser capture microdissection and multiplex-tandem PCR analysis of proximal tubular epithelial cell signaling in human kidney disease. PLoS One. 9(1):e87345. doi: 10.1371/journal.pone.0087345.
Zuryn S., Jarriault S. (2013). Deep sequencing strategies for mapping and identifying mutations from genetic screens. Worm. 2(3):e25081-10. Invited review.
Schlipalius DI., Valmas N., Tuck AG., Jagadeesan R., Ma L., Kaur R., Goldinger A., Anderson C., Kuang J., Zuryn S., Mau YS., Cheng Q., Collins PJ., Nayak M., Schirra HJ., Hilliard MA., Ebert PR. (2012). A Core metabolic enzyme mediates resistance to phosphine gas. Science. 338(9):807-810.
Zuryn S., Daniele T., Jarriault S. (2012). Direct cellular reprogramming in C. elegans: facts, models and promises for regenerative medicine. Wiley Interdiscip Rev Dev Biol. 1(1):138-152. Invited review.
Richard J.*, Zuryn S.*, Fischer N., Pavet V., Vaucamps N., Jarriault S. (2011). Direct in vivo reprogramming involves transition through discrete, non-pluripotent steps. Development. 138(8):1483-92. (*Co-first). Highlighted in DevelopmentFaculty of 1000 recommended.
Zuryn S., Le Gras S., Jamet K., Jarriault S. (2010). A strategy for direct mapping and identification of mutants by whole-genome sequencing. Genetics. 186(1):427-30. Featured as the issue cover. Zuryn S., Kuang J., Tuck A., Ebert PR. (2010). Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity. Mech Ageing Dev. 131(9):554-61.
Zuryn S., Kuang J., Ebert PR. (2008). Modulation of mitochondrial phosphine toxicity and resistance in Caenorhabditis elegans. Toxicological Sciences. 102(1):179-86.
Valmas N.*, Zuryn S.*, Ebert PR. (2008). Mitochondrial uncouplers synergise with the fumigant phosphine to disrupt mitochondrial membrane potential and cause cell death. Toxicology. 30;252(1-3):33-9. (*Co-first).
Saber SH*, Yak N*, Yong XLH, Bong R, Leeson H, Dai CY, Binder T, Lu S, Purushothaman R, Lenaerts A, Almeida-Souza L, Koludarova L, Er S, Hlushchuk I, Gaudin A, Singh S, Nyman TA, Harmer JR, Zuryn S, Wolvetang E, Talbo GH, Airavaara M, Battersby BJ, van Waardenberg AJ, Anggono V, Balistreri G, Joensuu M (2025) DDHD2 provides a flux of saturated fatty acids for neuronal energy and functions. Nature Metabolism. 7(10), 2117-2141. (*Co-first) Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages.Abrol R, Afroz SF, Curson JEB, Raven KD, Das Gupta K, Gunther KS, Jones A, Reid RC, Xiong Z, Gunter JH, Engel JA, Engwerda CR, Blumenthal A, Fairlie DP, Parton RG, Zuryn S, Kapetanovic R, Ramnath D, Sweet MJ. J Cell Sci. 2025 Oct 1;138(19):jcs264376. The mechanisms and roles of mitochondrial dynamics in C. elegans.Campbell D, Zuryn S. Semin Cell Dev Biol. 2024 Mar 15;156:266-275. doi: 10.1016/j.semcdb.2023.10.006. Epub 2023 Oct 31. Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function. Matsunaga Y, Qadota H, Ghazal N, Lesanpezeshki L, Dorendorf T, Moody JC, Ahier A, Matheny CJ, Vanapalli SA, Zuryn S, Mayans O, Kwong JQ, Benian GM. Commun Biol. 2024 Oct 17;7(1):1342. . C. elegans as a model for health and disease. Zuryn S. Semin Cell Dev Biol. 2024 Feb 15;154(Pt A):1-3. Hahn A., Hung GCC., Ahier A., Dai CY., Kirmes I., Forde BM., Campbell D., Lee RSY., Sucic J., Onraet T., Zuryn S. (2024) Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans. Cell Metabolism. S1550-4131(24)00291-2. Dai CY, Zhang H, Zuryn S. (2024) SoMarker: a genetic marker searching tool for Caenorhabditis elegans. G3 Genes|Genomes|Genetics. 14(10):jkae197. C. elegans as a model to study mitochondrial biology and disease.Onraet T, Zuryn S. Semin Cell Dev Biol. 2024 Feb 15;154(Pt A):48-58. Dai CY., Ng CC., Hung GCC., Kirmes I., Hughes LA., Du Y., Brosnan CA., Ahier A., Hahn A., Haynes CM., Rackham O., Filipovska A., Zuryn S. (2023) ATFS-1 prioritises mitochondrial genome repair to enhance cellular robustness in C. elegans. Nature Cell Biology. (In Press). C. elegans as a model to study mitochondrial biology and disease.Onraet T, Zuryn S.Semin Cell Dev Biol. 2024 Feb 15;154(Pt A):48-58. doi: 10.1016/j.semcdb.2023.04.006. Epub 2023 Nguyen-Dien GT, Kozul KL, Cui Y, Townsend B, Kulkarni PG, Ooi SS, Marzio A, Carrodus N, Zuryn S, Pagano M, Parton RG, Lazarou M, Millard SS, Taylor RW, Collins BM, Jones MJ, Pagan JK. (2023) FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. EMBO Journal. 42(13):e112767. Onraet T., Zuryn S (2023) C. elegans as a model to study mitohcondrial biology and disease. Semin Cell Dev Biol. S1084-9521(23)00101-5. Kirmes I. & Zuryn S (2022) LONP-1 aids propagation of deleterious mtDNA. Nature Cell Biology. 24(2):127–128. Richman TR., Ermer JA., Siira S., Kuznetsova I., Brosnan CA., Rossetti G., Baker J., Perks K., Szappanos HC., Viola HM., Whiley NG., Hool LC., Zuryn S., Rackham O., Filipovska A. (2021) Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan. Aging Cell. :e13408. doi: 10.1111/acel.13408.
Ahier A., Dai CY., Kirmes I., Cummins N., Götz J., Hung GCC., Zuryn S. (2021) PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome. Cell Reports. 35(9): 109203. doi: 10.1016/j.celrep.2021.109203.Featured as the issue cover.Featured in “preLights” by The Company of Biologists.
Brosnan CA., Palmer AJ., Zuryn S. (2021) Cell-type-specific profiling of loaded miRNAs from Caenorhabditis elegans reveals spatial and temporal flexibility in Argonaute loading. Nature Communications. 12:2914.Faculty of 1000 recommended. Cummins N., Tweedie A., Zuryn S., Bertran-Gonzalez, J., Götz J. (2019) Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria. EMBO Journal. 38(3). pii: e99360.
Hahn A., Zuryn S. (2019) Cellular mitochondrial genomic landscape in disease. Trends in Cell Biology. 29(3):227-240. Hahn A., Zuryn S. (2019) Mitochondrial genome (mtDNA) mutations that generate reactive oxygen species. Antioxidants. 8(9). e392. doi: 0.3390/antiox8090392
Ahier A., Dai CY., Tweedie A., Bezawork-Geleta A., Kirmes I., Zuryn S. (2018) Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism. Nature Cell Biology. 20(3):352-360. Featured as the issue cover.Commentary in The Scientist.
Bezawork-Geleta A., Wen H., Dong L., Bing Y., Vider J., Boukalova S., Krobova L., Vanova K., Zobalova R., Sobol M., Hozak P., Novais SM., Caisova V., Abaffy P., Naraine R., Pang Y., Zaw T., Zhang P., Sindelka R., Kubista M., Zuryn S., Molloy MP., Berridge MV., Pacak K., Rohlena J., Park S., Neuzil J. (2018) Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints. Nature Communications. 9:2221.
Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. (2014). Sequential histone-modifying activities determines the robustness of transdifferentiation. Science. 345(6198):826-829. Commentary in Developmental Cell.Faculty of 1000 recommended.
Wilkinson R., Wang X., Kassianos AJ., Zuryn S., Roper KE., Osborne A., Sampangi S., Francis L., Raghunath V., Healy H. (2014). Laser capture microdissection and multiplex-tandem PCR analysis of proximal tubular epithelial cell signaling in human kidney disease. PLoS One. 9(1):e87345. doi: 10.1371/journal.pone.0087345.
Zuryn S., Jarriault S. (2013). Deep sequencing strategies for mapping and identifying mutations from genetic screens. Worm. 2(3):e25081-10. Invited review.
Schlipalius DI., Valmas N., Tuck AG., Jagadeesan R., Ma L., Kaur R., Goldinger A., Anderson C., Kuang J., Zuryn S., Mau YS., Cheng Q., Collins PJ., Nayak M., Schirra HJ., Hilliard MA., Ebert PR. (2012). A Core metabolic enzyme mediates resistance to phosphine gas. Science. 338(9):807-810.
Zuryn S., Daniele T., Jarriault S. (2012). Direct cellular reprogramming in C. elegans: facts, models and promises for regenerative medicine. Wiley Interdiscip Rev Dev Biol. 1(1):138-152. Invited review.
Richard J.*, Zuryn S.*, Fischer N., Pavet V., Vaucamps N., Jarriault S. (2011). Direct in vivo reprogramming involves transition through discrete, non-pluripotent steps. Development. 138(8):1483-92. (*Co-first). Highlighted in DevelopmentFaculty of 1000 recommended.
Zuryn S., Le Gras S., Jamet K., Jarriault S. (2010). A strategy for direct mapping and identification of mutants by whole-genome sequencing. Genetics. 186(1):427-30. Featured as the issue cover. Zuryn S., Kuang J., Tuck A., Ebert PR. (2010). Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity. Mech Ageing Dev. 131(9):554-61.
Zuryn S., Kuang J., Ebert PR. (2008). Modulation of mitochondrial phosphine toxicity and resistance in Caenorhabditis elegans. Toxicological Sciences. 102(1):179-86.
Valmas N.*, Zuryn S.*, Ebert PR. (2008). Mitochondrial uncouplers synergise with the fumigant phosphine to disrupt mitochondrial membrane potential and cause cell death. Toxicology. 30;252(1-3):33-9. (*Co-first).